Advanced Lipid Testing – when “bad cholesterol” isn’t good enough

In an earlier post, I reviewed the new ACC/AHA guidelines for treating cholesterol.  These guidelines recommend basing treatment solely on LDL-c or the “bad cholesterol”, treating when it is high but not to a specific target.  Over the last several decades, lowering levels of LDL-c has resulted in a decreased rate of heart disease that combined with advances in treatment has also reduced the death rate from heart disease.

Despite these advances, heart disease remains the number one killer of Americans.  A 2009 study from ULCA demonstrated that half of people who have heart attacks have relatively “normal” levels of LDL-c cholesterol.  What are we missing in these people?  Is their another marker we could measure to more accurately predict risk?  

What is Cholesterol testing?

Low Density Lipoprotein is the “sticky stuff” that clogs arteries.  Cholesterol is a carrier for the lipoproteins that circulate in our blood.  The more lipoproteins in you blood, the greater your risk for heart disease.  Historically we have used the measurement of LDL cholesterol to act as a surrogate measure of these sticky proteins because it was the best we had.  We have had a tremendous impact on heart disease by treating cholesterol.

The problem with LDL-c measurement is that it is a calculation based on certain assumptions about how the sticky proteins are distributed in the system.  The model breaks down when triglycerides (another component of a cholesterol panel) are elevated.  When this occurs, the sticky proteins are not distributed evenly and you have a lower level of LDL-c than the true level of sticky proteins that cause plaque.  The result is that the traditional LDL-c reading will underestimate the risk of heart disease – helping to account for the “half of heart attack victims with normal cholesterol.”

What other markers are there for lipid testing?

Many measurements have been evaluated to see if there are better predictors of heart disease than LDL-c.  3 of the most promising are Non-HDL-c, Apo-B and LDL particle number (LDL-p).  

Non-HDL-c is a calculation that simply subtracts the HDL-c level from the Total Cholesterol level in a standard lipid panel.  For those at highest risk of heart disease, a non-HDL-c level over 130mg/dl is associated with increased risk of heart disease regardless of what the usual LDL-c is.  The advantage of this reading is that it can be determined at no additional cost from a standard lipid panel.  Disadvantages are variability based on fasting state and that it may not predict how well medication is reducing risk.

Apo-B is a protein that is deposited in the walls of arteries to create plaque.  It is carried through the system by cholesterol.  The more Apo-B in your system the greater your risk of heart disease.  Each particle of low density lipoprotein contains 1 molecule of APO-B.  Studies have shown that Apo-B levels can remain elevated even in setting of “normal” cholesterol levels.

LDL-p directly measures the particles of low density lipoprotein that account for the risk of heart disease.  Studies have shown that LDL-p can be elevated even when cholesterol levels are normal.  Information presented at the most recent American Cardiology Conference demonstrated that treating patients to a normal LDL-p had a 22-25% reduction in heart attacks than those treated to traditional goal cholesterol values.

How does this affect my practice?

I see patients at increased risk of heart disease on a daily basis.  I generally order a traditional cholesterol panel on all patients.  When their history indicates an increased risk of heart disease – due to family history, diabetes, hypertension or obesity, I will order an LDL-p as well.  I will also order an LDL-p if their traditional cholesterol panel shows high triglycerides.  I find this test to be one of the easiest to interpret as there are direct values that correlate with risk.  It also does not require fasting – making it a very convenient test indeed!

So while not everyone needs to have their LDL-p measured, it is important not to simply accept a cholesterol reading at face value.  Like all tests, it needs to be interpreted in the setting of your individual risk factors and other medical conditions.  Knowing your real risk of heart disease is a necessary initial step towards improving your health!

The path to wellness begins with a proper diagnosis. 


It’s been 3 months since I launched The DiagnosisMD.  As I reflect on what we’ve done in this time, it’s been a great experience for me – hopefully you have learned as much from reading my blog as I have writing it.

So far, over 1600 views from over a dozen countries, and many followers on Facebook, Twitter, LinkedIn and Google+!  Next phase will be adding a YouTube channel – stay tuned!

Thank you for reading, and let me know any topics of interest!

The path to wellness begins with a proper diagnosis

Fertility after the pill

I recently referenced a NY Times article summarizing a study showing a link to stress and fertility problems.   As an Internist and Primary Care Physician, I am often asked fertility questions by my patients that are trying to conceive.  “I’ve been on the pill for years and now I want to get pregnant.  Will it be hard for me to conceive?” is an incredibly common question.  The answer depends on many factors.   The main determinants of fertility are age and the regularity of ovulation before and after oral contraception use.

Does duration of pill use affect fertility?

The amount of time a woman used oral contraceptives prior to attempting conception has little to do with time to recovery of their prior cycle.  Most physicians recommend waiting for a cycle off the pill before attempting conception, however, it is possible to get pregnant right away.  Therefore, if you do not wish to get pregnant right away, an alternative, non-hormonal, method of contraception is recommended.

Oral contraceptives use hormones to suppress ovulation.  If a woman does not ovulate, she can not get pregnant.  Once oral contraceptives are stopped, the hormones from the pill are out of the system in 3-4 days.  After that, the body’s own hormonal rhythm takes over.  So, if a woman had a regular ovulatory cycle before starting the pill, it is reasonable that she will resume that cycle shortly after stopping.  If the pill was being used to regulate an irregular cycle, then the ovulatory issues that existed prior to the pill will need to be addressed after the pill.

Fertility after the pill is mostly determined by fertility prior to the pill.  Duration of oral contraception use is not a major factor.  It takes the average couple about 8 months to conceive, so fertility testing prior to 1 year of attempting conception is not recommended unless there is an underlying issue that may be contributing to infertility.

How does this affect my practice?

A good history about why a person was using the pill, determining any risk factors for fertility issues is most important in answering the question of “will I have fertility issues after the pill?”  Once a sense of how regular a woman was before starting the pill, we can begin to predict what issues, if any, may need to be addressed.  A conversation with your doctor can lead to a plan, alleviate stress and allow you to enjoy the journey to a new part of your life.

The path to wellness begins with a proper diagnosis

Colon Cancer – An Ounce of Prevention….

Breaking bad news is one of the hardest parts of my job.  There are times that I have to tell someone they have a new diagnosis – whether diabetes, a sexually transmitted disease or cancer – and it is not easy.  It is even more difficult when I know that some diagnoses can be PREVENTED!  So I am a huge advocate for preventing a disease whenever I can.  March is Colorectal Cancer Awareness month – and this week’s post is an update on how to prevent ever having to hear your doctor utter the horrible words – “You have colon cancer.”

Colon and Rectal cancer will be diagnosed in over 125,000 people in the US this year.  Over 50,000 people will die from it.  Colon cancer is the 3rd most common cancer in the United States.  And the majority of cases are preventable.  So how are colon and rectal cancer prevented?  By screening for them – doing tests that look for cancer – or ideally pre-cancerous lesions, and removing them.  How do we decide when and what tests to do?  By looking at your medical history and your family medical history and determining your risk.

For those at average risk, the current recommendations for colon cancer screening is to begin at age 50.  Why age 50?  At age 50, the likelihood of colon cancer or a colon polyp – a bump in the tissue of the colon that can turn into cancer – becomes high enough that the benefit of doing a test and removing the lesions outweighs the risk of the testing and the procedure.

So what increases your risk of colon or rectal cancer?

  • Colon cancer or precancerous polyps in a first degree relative (parent, sibling)
  • Prior colon polyps yourself
  • A  history of Ulcerative Colitis
  • A family history of a hereditary colon cancer syndrome – familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC)

How do we screen for colon cancer?

  • Fecal Occult Blood Testing (FOBT)
  • Colonoscopy
  • Flexible Sigmoidoscopy
  • Barium Enema
  • CT Colonoscopy (also called a Virtual Colonoscopy)

 What are the advantages and disadvantages of each screening method?

  • FOBT  – done yearly; a small amount of stool is placed on a card, and a chemical added to see if there is any blood in the stool.  Best done with 3 consecutive bowel movements at home and returned to the doctor.  This helps detect cancer because polyps or cancer often bleed.  If blood is detected, a colonoscopy is required.
  • Colonoscopy – this a procedure,  done under anesthesia or sedation, where a flexible tube with a camera is inserted in the rectum and passed through the entire colon.  It directly visualizes the colon and any polyps can be removed (preventing them from becoming cancer).  It should be done at least every 10 years (if totally normal) and more frequently depending on risk and findings.  The 10 year interval is based on studies that show it takes about 10 years for a polyp to turn into cancer.  It requires a “prep” – emptying the colon of any stool the day prior to the procedure.  This is the “gold standard” for colon cancer prevention.
  • Flexible Sigmoidoscopy – this is a procedure, where a flexible tube similar to a colonoscopy tube is inserted in the rectum, and the first two feet of the colon are looked at for polyps or cancer.  If they are detected, they can be removed.  It requires a prep to clean the colon.  It can miss any polyps beyond the two feet of colon closest to the rectum.  If any polyps are found, either a colonoscopy or a barium enema to look at the rest of the colon are recommended.
  • Barium Enema – this is an X-ray test where barium is inserted into the rectum and outlines the inside of the colon.  An X-ray is taken to see the outline, allowing polyps that change the outline to be seen.  It requires a prep before the procedure to empty the colon.  If the study is abnormal, a colonoscopy is required.
  • CT Colonoscopy (Virtual Colonoscopy) – a study using a CT scan and computer reconstruction to see the inside of the colon, looking for polyps or cancer.  It takes less time than a traditional colonoscopy.  There is radiation exposure. It does require the same prep as a colonoscopy, and a small tube is inserted in the rectum to pump air into the colon to allow for better imaging.  If the study is abnormal, a colonoscopy is required.

How does this affect my practice?

I recommend a colonoscopy for all my patients over 50 years old.  If there is a family history of colon cancer I recommend starting 10 years before the relative’s age when they had colon cancer or age 50 – whichever is sooner.

Most people dread the prep – cleaning out their colon more than the procedure itself.  Most people sleep through the actual procedure.  The preps have gotten better in that you don’t need to drink as large a volume of liquid as in the past.  It could be considered the most useful cleanse ever!  

I also recommend FOBT yearly between colonoscopies, though current guidelines to not require this.  I make this recommendation because FOBT is easy, and people may delay their colonoscopy or a polyp may develop a little faster than the usual 10 years.

As far as flexible sigmoidoscopy and barium enema, I only recommend them if there is a reason a colonoscopy can not be done.  CT colonoscopy gives a great image of the colon, and if totally normal gives good reassurance that there is no colon cancer.  However, if there is an abnormality, a colonoscopy must be done, requiring a second prep and procedure.

Colon cancer is preventable – and if diagnosed early, curable.  The important thing is to talk to your doctor about your risk and get screened – any method of screening is better than nothing!  I recommend colonoscopy as it allows the best visualization of the colon – and removal of polyps at the same time – one stop shopping.  Telling someone we prevented them from getting cancer is much more fulfilling than telling them they have colon cancer!

The path to wellness begins with a proper diagnosis

Some useful links:

CDC colon cancer screening guidelines

American Cancer Society colon cancer detection guidelines

American Cancer Society colon cancer overview


Addiction and Substance Abuse

Of all the illnesses I treat, conditions I diagnose and problems I am presented with, one of the most difficult is addiction. Addiction can be to many things – alcohol, illegal drugs, prescription drugs, smoking, food, exercise, gambling and other behaviors. Addiction affects not only the person involved, but their entire network of friends and family.

One of the biggest challenges in diagnosing addiction is that the person may not admit there is a problem. A family member may speak to me, but the conversation usually ends with – “don’t tell them I spoke to you, I just wanted you to know what is happening…” I can not force a patient to come speak to me, nor can I tell that family member anything about what I may have discussed with the patient (without their permission). After awhile, their addiction becomes a palpable element in the room that no one can speak about. I will ask about it, but if the patient will not acknowledge an issue, there is little to be done.

What causes addiction?

Addiction is defined as a chronic, relapsing disease characterized by compulsive drug seeking and use despite harmful consequences as well as neuro-chemical and molecular changes in the brain.    Addiction crosses lines of race, economics and education.  In 2010 it was the 15th leading cause of death in the United States.

When exposed to a potentially addicting substance, the brain produces a substance called dopamine.  This activates the brain’s “reward circuitry” which will begin to create cravings.  Some people are genetically predisposed to be more susceptible to this, so addiction can run in families.

In addiction to the reward center, cognition and understanding are affected.  The prefrontal cortex of the brain – the higher brain involved in thinking and reasoning becomes affected as well.  A phenomenon called Restricted Awareness occurs – the addicted person becomes unable to fully grasp the deficits their behavior has created – so there is a neuro-chemical issue and not just denial at work.  Similar changes are triggered by high fat/high sugar foods as are by drugs.

Drugs of abuse - from the National Institute of Drug Abuse
Drugs of abuse – from the National Institute of Drug Abuse

Physical effects of addiction

The changes in the brain are consistent across substances.  Different substances can have different effects on other parts of the body.  While this is not a comprehensive list, some commonly abused substances and their physical consequences are:

  • Marijuana can damage the lungs just as cigarettes do
  • Cocaine increases plaque building in the arteries, increasing the risk of heart attacks
  • Heroin suppresses breathing
  • Prescription pain killers slow down the digestive system, as well as potentially cause liver and kidney damage
  • Alcohol damages the liver
  • Any drug that is injected, especially when needles are shared, increases the risk of Hepatitis B and C (which can cause liver failure and liver cancer) as well as HIV

How is addiction treated?

Treatment for addiction begins with a patient recognizing that their behavior is affecting their life in a negative way, and that they are unable to control it without help.  Treatment programs can be inpatient – meaning admission to a facility for detoxification and treatment with 24/7 monitoring or outpatient – meaning going to appointments with physicians and counselors while remaining in the community.

Regardless of the setting, treatment involves

  • Detoxification – stopping the substance of abuse and treating physical withdrawal
  • Counseling to help the addicted person process what they have been through and develop coping strategies for the stresses that led to the addiction
  • Medications may be used either short or long-term to block the effects of drugs of abuse, prevent activation of the rewards center in the brain or treat other issues related to substance abuse

Successful treatment can reverse the brain changes that occur with addiction, just as smoking cessation reduces the risk of heart attack, stroke and lung cancer.

Brain scan showing near normal activity after14 months of sobriety
Brain scan showing near normal activity after 14 months of sobriety. Source: National Institute of Drug Abuse


How does this affect us?

Substance abuse takes many forms, and I need to be alert to signs that there may be issues – clues from behavior as well as physical findings.  Direct questions from a physician are usually answered with some truth.  That can begin a conversation about starting a treatment program.

In the case of prescription drug abuse, physicians have some additional tools.  Several states have databases that physicians can register for to see if prescriptions are being filled by multiple doctors and from which pharmacies and on what dates.  When you can show a person what their behavior has been, it again can be the beginnings of help.  A physician also needs to have a plan about stopping addictive prescriptions to prevent or end the cycle of abuse a person is in.  As a friend of mine who once became addicted to prescription pain killers told me that he hoped that a doctor would “catch” him so that he could get the help he knew he needed but did not know how to ask for.

If you or someone you know needs help:

National Institute of Health information of drugs of abuse –

Narcotics Anonymous –

Or see your physician and ask for help!

The path to wellness begins with a proper diagnosis

Vaccines for HPV – Lies, Damn Lies and Statistics

In 2006, a new vaccine was introduced in the US – a vaccine for the Human Papilloma Virus (HPV).  This virus is responsible for most cases of cervical cancer, some throat, penile and anal cancers, as well as genital warts.  The vaccine is effective against the 4 strains of HPV that cause the majority of cervical cancer and genital warts.  It is given as a series of 3 shots over a 6 month time period, and is approved for females and males, ages 11-26.  There are two brands of vaccine, Gardisil and Cervarix, currently FDA approved in the US.  Recently, there has been a lot of media attention to HPV vaccines, leading to a lot of confusion about what the vaccine does and how safe it is.  As the father of a 12 year old girl, I thought I’d share my views and research.

What is HPV?

Human Papilloma Virus is the most common Sexually Transmitted Infection and responsible for most cervical cancer, as well as genital warts in both sexes.  It can also cause throat, penile and anal cancer.  The 4 strains of the virus that cause the most harm are 6,11,16, and 18, which are the strains in the vaccine.  HPV causes almost 34,000 cancers a year, with about 2/3 of them in women.  Almost 12,000 of the cancers are cervical cancer, which is usually treated by removal of the cervix and uterus (hysterectomy) which makes it impossible for a woman to have children.  Over 14 million people per year get infected with HPV.
HPV can be tested for in women during a PAP smear, hopefully identifying lesions before they become cancer.  However, there is no reliable test in men, other than doing a biopsy on a wart or other visible lesion.

What is the controversy?

Mark Twain once said, “There are 3 kinds of lies: Lies, Damn Lies and Statistics.”  All three have been used in the argument for and against vaccines.  Vaccines in general provoke very strong reactions from many people. Vaccines have been blamed for many conditions and reactions completely separate from the diseases the vaccines were meant to prevent.  There have been vaccines that have been recalled and discontinued because the risk of side effects was higher than the disease rate – a vaccine for Rotavirus and for Lyme Disease have both been discontinued.  There are immune reactions that are possible that can have serious health consequences, but these are not very common.  Allergic reactions to a vaccine are possible, just as they are possible with other medications or foods.  These reactions need to be considered and a good medical history obtained before they are administered.  However, I think that as medical science has progressed, we have lost sight of the devastation these preventable diseases  caused.  
I want to be very clear and state that there is NO LINK BETWEEN VACCINES AND AUTISM.  There was one scientist who made that claim and published research making that claim.  His research has been shown to be falsified, the journal that published the study issued a retraction and the scientist has had his medical license revoked.
Out of 57 million doses of HPV vaccine given through March of 2013, there have been 22,000 reactions reported.  Of those, less than 1800 have been considered severe reactions, mostly headache, nausea and fainting.  Enough people fainted that it is recommended that people wait 15 minutes after the vaccine before leaving the doctor’s office.  There have been about 30 deaths reported after the vaccine – but  none of those deaths have been shown to be directly related to the vaccine.  For example, if someone died in a car accident after receiving the HPV vaccine, it is reported.
Much of the recent controversy regarding HPV vaccine comes from 2 events in the past year.  In one, a physician submitted a case report of a 16 year old girl with irregular periods and eventual ovarian failure – with the symptoms beginning a few months after receiving the vaccine.  There was no evidence linking her condition to the vaccine, and it is known that in cases of early ovarian failure a cause is only found 10% of the time.  In addition, the reporting physician had strong personal beliefs that may have biased her reporting of the case.
The other event was when Katie Couric had a physician on her talk show who was involved in the development and testing of the HPV vaccine.  This doctor in several interviews did not question the safety of the vaccine or it effectiveness, but rather called attention to the fact that it is not yet known how long the vaccine lasts, and a booster may be needed.  She also questioned the need for the vaccine when PAP smears could detect the cervical cancer early.  However, HPV causes 20,000 cases of non-cervical cancer per year which would be missed.  Her statements also assume a much higher rate of women going for PAP smears than is likely to occur.  Ms. Couric did not give equal airtime to her own medical expert, her comments supporting vaccination were on the show’s website.  Ms. Couric did issue an apology after the show aired acknowledging that not enough airtime was given to talk about the benefits and safety of the HPV vaccine.

How does this affect us?

Our ability to treat disease has advanced tremendously in the past 100 years.  The rate of mothers dying during childbirth was reduced dramatically by having doctors and nurses wash their hands prior to delivering the baby… simply by preventing infection!  Today, it is accepted that by not smoking, maintaining a healthy body weight, normal blood pressure and cholesterol, we can prevent heart disease.  If we stop preventing disease, a healthy life and life expectancy would be very different from what it is today.  The CDC estimates that if we stopped preventing diseases with vaccines:
  • 13,000 – 20,000 people a year, mostly children, in the US would contract polio, requiring braces, crutches, wheelchairs and breathing machines
  • Almost everyone in the US would get measles, 20% of whom would need to be hospitalized, and 450 would die per year in the US, and 2.7 million worldwide
  • Haemophilous Influenzae (Hib) would cause 20,000 cases of meningitis or epiglottis in the US, killing 600 people per year.  About 1 in 200 children under 5 would be infected, and those that survive are often left deaf, with seizures or mental impairments
  • Almost all children would contract whooping cough, with about 9000 deaths per year
  • Pneumococcus would infect 63,000 Americans yearly, killing 10% of those infected
  • Rubella, while mild in most children and adults, causes birth defects in 90% of children whose mothers got infected while pregnant, causing heart defects, deafness, cataracts and mental retardation
  • Mumps would infect 300,000 people a year, and causes deafness in about 6% of cases.  It also caused miscarriages in women infected while pregnant
  • Hepatitis, Diptheria, Tetanus and Chickenpox are all diseases with potential long term consequences that we are preventing with vaccines
Vaccines are some of the most closely monitored treatments in medicine, both because the diseases they prevent are serious, and the consequences of not getting it right are real as well.  This is a great conversation to have with your physician during an Annual Physical.  My daughter will be getting her vaccination shortly.
The path to wellness begins with a proper diagnosis

Diagnosis of Arthritis

One of the most common reasons people go to the doctor is for joint pain.  “My knee hurts and swells after I walk, it hurts when it rains or it takes me awhile after I wake up before I can move well” are all often heard symptoms in patients with arthritis.  In a recent Center for Disease Control publication  22.7% of adults (52.5 million people) reported being told by a doctor they had arthritis, and 9.8% (22.7 million people) stated that their activity levels were reduced because of arthritis.

But what is arthritis?  Arthritis is inflammation in a joint.  There are multiple causes and types of arthritis, each with its own set of symptoms, complications and treatment recommendations.

The two main types of arthritis are Osteoarthritis and Autoimmune Arthritis.  They share some features and are very different in others.  Common symptoms between the two types are pain, joint swelling and stiffness.  Which joints are involved and the pattern of swelling and stiffness can differentiate between the two.  In addition, X-ray and blood test results are different in Osteoarthritis and Rheumatoid Arthritis (the most common form of Autoimmune Arthritis).


Osteoarthritis is generally referred to as “wear and tear” arthritis.  It occurs when a damaged joint fails to repair itself.  Osteoarthritis can effect only 1 joint, a few joints or be generalized.  It is the most common joint disorder.  It’s major symptoms are:

  • joint pain
  • restricted movement in the joint
  • loss of function

In general, osteoarthritis pain gets worse with use and improves with rest.  There can be stiffness in the morning which usually improves in under 30 minutes.  Usually, the appearance on an X-Ray does not match the symptoms – so a person with osteoarthritis could have significant pain but a normal X-ray.  Blood tests show normal to minimally elevated signs of inflammation.

Osteoarthritis of the hands involving the end of the fingers

The most commonly affected joints are:

  • Knees and hips
  • Junction of the fingers and hand
  • Finger joints and bunion joint of feet
  • Joints at the base of the neck (cervical spine) and the lower back (lumbar spine)

Other joints can certainly be affected, especially in the setting of a prior injury.

Another specific characteristic of osteoarthritis is the pattern of joint pain.  Osteoarthritis tends to involve one joint at a time, where as rheumatoid arthritis tends to involve joints on both sides of the body at the same time.  The knee is the most common joint affected.

In terms of treatment, the guiding principle is to focus treatments based on a patient’s symptoms and functional issues.

  • Weight loss and exercise can improve knee and hip pain dramatically
  • NSAIDs (ibuprofen, naproxen)
  • Topical pain medications (capsaicin, topical NSAIDs)
  • Joint injections
  • Supplements – there is some evidence but the quality of the studies is poor
    • Vitamin D
    • Glucosamine-Chondroitin
    • Tumeric, Paeony and Miatake have been shown to have properties similar to NSAIDs

Rheumatoid Arthritis (RA)

Like all the autoimmune arthritis syndromes, RA is an illness that affects more than just the joints.  It is characterized by inflammation that causes joint tissue damage.  There is a genetic predisposition as well as environmental triggers that are not well-defined.  The peak age of onset is between 30-50 years of age.

A typical patient will present with some of the following:

  • Pain and stiffness in multiple joints – usually the wrist and fingers first
  • Morning stiffness that lasts for more than 1 hour
  • Fatigue, fevers, weight loss

In 2010, the American College of Rheumatology updated the criteria for making a diagnosis of RA.  It is a point based scale that  take aspects of multiple features including joint pain, physical and lab features of the illness to give a score that helps make the diagnosis.  The updated criteria can be found here

Hand changes from severe Rheumatoid Arthritis

Blood tests for RA are not an absolute requirement, but two specific tests, Rheumatoid Factor and Anti-citrullinated protein are positive in about 50-60% of people.  In addition, a test for inflammation like C-reactive protein or sedimentation rate can be used to follow disease activity.

X-rays of the hands and feet are usually done at the time of diagnosis to check for joint damage.  Once the diagnosis is established, treatment should be quickly and aggressively started – studies have shown that treating aggressively early in the disease can lessen permanent damage.

The goals of treatment are:

  • Minimize pain and swelling
  • Prevent joint deformity and damage
  • Maintain quality of life
  • Control non-joint symptoms

Treatments for RA are called DMARDS – Disease modifying anti rheumatic drugs – are grouped into Biologic and Non-biologic treatments.  Non-biologic treatments are medications such as methotrexate that are used to reduce inflammation.  Biologic medications are newer treatments that block cytokines – chemicals that promote inflammation – such as Tumor Necrosis Factor (TNF).  They are usually given either intravenously or by injection.  Steroids and joint injections can also provide relief.  All treatments have potential side effects that patients need to discuss with their doctors to determine their proper therapy.

Some supplements have been shown to be effective at improving symptoms – fish oil when combined with DMARDS improved results over medication alone.  The supplements with NSAID like activity can also improve symptoms.  Exercise has been shown to decrease inflammation in joints as well as improve joint function, and should be part of every treatment regimen.

How does this affect my practice?

It takes a good history to differentiate Osteoarthritis from RA.  So working with someone to get a sense of their type of pain, and how it affects them on a daily basis is essential to a proper diagnosis.  Arthritis is a diagnosis with many subtleties – each variation carries its own specific issues, treatments and side effects.  The proper diagnosis provides the foundation for safe and effective treatment.

The path to Wellness begins with a proper Diagnosis

Test me for everything

An Annual Physical is one of my favorite visits. It’s an appointment specifically designated to review your health – both where you are now and where you are heading. It’s the body’s status update. It’s also where I feel I get to know a person a little better, more about your life in general, not just your blood pressure or back pain. Besides having a conversation about your health, a blood test is usually performed. Often, when we get to drawing blood at a physical exam, a patient will say, “Test me for everything.”  Obviously, everything is not possible – so a discussion of what “everything” entails is needed. 

Often, patients use “everything” as a signal for testing for sexually transmitted diseases (STDs).  It is important to know that HIV can not be tested for without your request – so do not assume it is being tested – ASK FOR IT!

Other STD tests usually include HIV, syphilis, gonorrhea, chlamydia and Hepatitis B & C.  Herpes can be tested for in the blood as well, but the test only shows whether a person has been exposed to the Herpes virus, it does not give information on contagiousness or disease activity.

HPV is tested for in women during a PAP smear.  It is a test done on cervical cells – it is not a blood or urine test.  There is no test for men for HPV, unless there is a lesion – usually a wart – that can be biopsied.

So what are the usual blood tests done at a physical?

It depends on your age and gender. The blood tests I order fairly universally:

  • blood count (CBC)
  • sugar (glucose)
  • liver function (AST, ALT)
  • kidney function (BUN, Cr)
  • lipid panel (cholesterol)
  • thyroid function (TSH, Free T4)
  • urinalysis

Often tested, but not “mandatory”

  • iron levels
  • vitamin B12
  • vitamin D

Other tests determined by age, gender or a medical condition

  • high sensitivity C-reactive protein (cardiovascular risk)
  • hemoglobin A1c (for further assessment of diabetes)
  • urine protein (for people with diabetes or hypertension)
  • prostate specific antigen (PSA) – this is ordered after a discussion about risk and benefits
  • other tests can be considered depending on individual risk – advanced lipid testing, imaging studies, stress tests – these depend on your specific medical needs and are not “one size fits all”

Do I have cancer?

One of the most common questions asked when we draw blood is can you tell if I have cancer? Blood tests for cancer or genetic information are not routinely done, with the exception of the PSA in men for prostate cancer.  While there are tests that exist for following some cancers, they have not improved diagnosis – especially the CA-125 test that is touted in many email chain letters for finding ovarian cancer – it is not a diagnostic test but rather a test for following someone with ovarian cancer. Using tests improperly leads to confusion, anxiety, more testing and misdiagnosis!

More cancers can be detected or screened for with specific tests other than blood tests. Colon cancer, breast cancer, cervical cancer and lung cancer all have screening tests (procedures) that improve detection. There are many guidelines as to when these tests should be done – the bottom line is that each person should discuss their individual risks with their doctor to determine what tests should be done, as well as when and how often!

This leads to the biggest issue of testing – interpreting the information in a meaningful way for you.  The FDA recently forced a home genetic testing company, 23 and Me, to stop marketing their kits due to quality and interpretation issues. As more tests are developed, our need to synthesize this information to make good decisions is becoming more apparent.

So, “everything” means different things to different people – so be specific if there is something you wish to have tested.  You can’t assume it is part of everything.  An Annual Physical gives you a snapshot of where you are, and serves as a guide for how to get to where you want to be. Have a conversation with your doctor about your health fears – an annual physical is the time to chart your path to health!

The path to wellness begins with a proper diagnosis

Testosterone Therapy – MANopause or Marketing?

Fatigue, weight gain, decreased sex drive and depression are very common complaints, especially as men age.  There are many diagnoses associated with such symptoms – obesity, diabetes and hypothyroidism are some examples.  They can also be associated with hypogonadism – which in men – is low testosterone or LowT.

What is Testosterone?

Testosterone is a hormone made in the testicles.  It’s production is controlled by other hormones in the pituitary gland, which senses the testosterone level in the body and directs production.  Testosterone is involved in genital development and other sex characteristics such as deepening of the voice, body hair, and sex drive.

How is Testosterone measured?

Testosterone is measured with a blood test.  There are two values that can be checked – total testosterone and free testosterone.  Free testosterone is the amount of hormone circulating that is directly and instantly available to the body, and not tied to another molecule in the system.

Normal levels of total testosterone range from 300-800 mg/dl.  One of the difficulties in measuring testosterone is that the value varies throughout the day and can be affected by a recent meal, exercise or the amount sleep you had prior to the test!

How is Testosterone supplemented?

Testosterone is not digestible, so it must be administered topically as a patch, cream, or gel, or injected into a muscle.  Each method has its pluses and minuses.

Topical medications are convenient, but may cause skin irritation.  There may be irregular absorption of the testosterone through the skin.  Also, if the testosterone is not completely absorbed it can be transferred to someone else’s skin – an important consideration if there are children or women (especially if pregnant).

Injections deliver a more precise dose and there is no risk of transferring the medication to someone else, but an injection every 2-4 weeks may be painful and less convenient – whether done at home or in a physician’s office.

How does Low Testosterone develop?

Damage or dysfunction of the testicles or pituitary gland either from medications, tumors or other problems can cause low testosterone.    Anabolic steroids – those used as performance enhancing drugs in sports – can lower testosterone levels among other side effects.  It was for severe deficiency around early development or testicular damage that synthetic testosterone was initially prescribed and FDA approved for – not for helping aging men feel 30 again.

Testosterone levels normally begin to decline by about 1% per year after age 30 – but this is very variable.  This decline, especially when blood tests became routinely available to check testosterone levels, gave rise to terms like andropause, male menopause or manopause.  In the past 10 years, testosterone use in men over 40 has quadrupled, and has become a multibillion dollar industry.

Similar to hormone replacement therapy (HRT) for women, restoring hormone levels to an earlier age has been marketed as a way of turning back the clock, restoring youth and vigor – and treating some very common, non-specific symptoms.  It wasn’t until after decades of HRT that a large study was done demonstrating that rather than helping improve women’s health, HRT increased rates of heart attacks, stroke, breast cancer and endometrial cancer!

Recently, several studies have been published linking testosterone therapy with an increased risk of heart disease.  These studies have called into question the wisdom of testosterone supplementation in the absence of true hypogonadism.  One study found that in men 65 and older the risk of a heart attack doubles in the first 90 days after starting treatment and goes up by 2-3 times in men under 65 with a history of heart disease.  This and other studies have prompted the FDA to review the safety of testosterone therapy and a large study similar to the one done for HRT is now underway to determine the benefits and harms of testosterone therapy.

How does this affect MY practice?

As with most diagnoses, a good history of symptoms is essential to determine their cause.  How long symptoms have been present, what seems to improve them, what else is going on in one’s life all contribute to weight gain, sex drive, energy and mood.  Diet and exercise habits need to be explored as changes  can have a huge impact on well-being, including raising testosterone levels without supplementation.

After discussing symptoms and a physical exam is performed, lab tests can be ordered.  I usually check a total testosterone first – it is much less expensive and the results come back faster.  If it is low or borderline, adding the free testosterone can be helpful to confirm or rule out the diagnosis.

Once all the data is back, we can review both symptoms and data together to decide if testosterone supplementation is likely to improve how one feels or if there is a different, more likely diagnosis.    Prior to starting supplementation I always check a blood count, cholesterol level, liver, kidney  and sugar tests as well as a PSA.  Supplementation can effect all these things which in turn can have health consequences.  For example, testosterone can cause the prostate to grow and may unmask an undiagnosed cancer – which is why supplementation therapy needs to be monitored.

At follow-up visits we assess the effect of treatment on both testosterone levels and most importantly, symptoms.  If the levels normalize and there is no change in how you feel, then as I wrote in an earlier post (What is a Diagnosis), treatment should be stopped and the diagnosis reconsidered.

The new evidence about the increased risk of heart attack will increase the conversations I have with my patients, especially those over 65 or with a history of heart disease, and likely increase how closely they are monitored.

Numbers from a lab without the context of symptoms don’t make a diagnosis.  Symptoms without the correlation of lab results often can not make a diagnosis.  Treating either in isolation does not improve health.  When used together, solutions can be found.

The path to wellness begins with a proper diagnosis